Igor Mierau

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Lactococcus lactis is an excellent host for the expression of a vast multitude of genes. Since my study of Microbiology and Microbial Genetics, I have been working for the last 25 years with Lactococci and other lactic acid bacteria in the areas of gene expression and fermentation. My inspiration is in multidisciplinary projects with close interaction with the client. One example is the development of a process for the production of the antibacterial enzyme lysostaphin from the micro-liter cloning-scale to the 1000-l production-scale. At NIZO I am responsible for gene expression projects using the in-house developed expression systems NICE for lactococci (nisin induced gene expression) and SURE for Bacillus subtilis (subtilin regulated gene expression).

For more information please refer to the publications and links underneath.

Mierau, I. 2007. Lactococcus lactis in the 21^st Century. Review

Mierau, I. 2005. 10 years of the NICE system in L. lactis. Review

Mierau, I. 2005. Yield optimization with the NICE system: Lysostaphin

Mierau, I. 2005. Industrial scale application of the NICE system: Lysostaphin

Gene Expression Services at NIZO

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Gene expression in Lactic Acid Bacteria LinkedIN Group