Developing infant nutrition products is a costly and time-consuming business. NIZO’s MicroColon model offers companies a solution to pre-screen ingredients, early in the development process. But could it be further optimised for the needs of infant nutrition companies? Guus explains this during this short video.
The market for probiotics and live biotherapeutic products continues to grow, as we increase our understanding of how they can improve health. Probiotic and pharmaceutical companies are looking for ways to use the naturally occurring bacteria in our bodies to amend dysbiosis of the gut, skin and more. Then they must get their products to market, quickly and cost-effectively. But there are many challenges that will define a company’s success or failure – especially when working with living organisms, that don’t always behave the way we want. In this webcast, NIZO's multidisciplinary and multi-stage approach in the probiotic journey, from discovery to health benefit substantiation, will be explained.
NIZO supports a healthy lifestyle by substantiating health benefits of food. In this video, Marjolijn Bragt of FrieslandCampina talks about her collaboration with @NIZO in an integrated approach to build a convincing case, in which the scientific and regulatory guidance, targeted preclinical studies, well-designed clinical trials, biomarker analysis and expert interpretation are combined.
NIZO supports a healthy lifestyle by substantiating health benefits of food. In this video, Ruud Albers, CEO of Nutrileads talks about his collaboration with NIZO in an integrated approach to build a convincing case, in which the scientific and regulatory guidance, targeted preclinical studies, well-designed clinical trials, biomarker analysis and expert interpretation are combined.
What does your ingredient’s impact on the gut microbiome reveal about potential health benefits?
There are trillions of micro-organisms living in the human gastrointestinal tract, including bacteria, viruses, fungi and protozoa. This multitude of gut microbiota has a much broader influence on the human body than simply the digestive system. It can affect metabolism, cognitive function, skin health, and more. And, conversely, health issues throughout the body can also influence the gut microbiome, such as psychological stress, use of medication, and more.
Probiotics, prebiotics, fibres, carbohydrates, proteins, etc. can impact the gut microbiota, potentially indicating a health benefit. Clinical trials can reveal not only whether your ingredient changes the microbiome, but also how the microbiome may alter physiological processes of the host. You get key information you can then validate through targeted clinical studies.
From start to finish, NIZO can design, support and coordinate the execution of your human intervention study on the impact of your ingredient on gut microbiota, including for example:
Depending on your question, NIZO can plan and complete a customised human study that meets your needs. We have strong expertise in clinical study execution, including faecal sampling, storage, handling and analysis.
We can use the same samples to look beyond changes in microbiota, into various properties of gut health such as immune or inflammation markers. And we can enrich this sample-based data with the questionnaire data on topics such as stool frequency and consistency.
Using our analytical expertise, including in bioinformatics, we then turn the masses of data generated, into actionable insight and guidance.