The market for probiotics and live biotherapeutic products continues to grow, as we increase our understanding of how they can improve health. Probiotic and pharmaceutical companies are looking for ways to use the naturally occurring bacteria in our bodies to amend dysbiosis of the gut, skin and more. Then they must get their products to market, quickly and cost-effectively. But there are many challenges that will define a company’s success or failure – especially when working with living organisms, that don’t always behave the way we want. In this webcast, NIZO's multidisciplinary and multi-stage approach in the probiotic journey, from discovery to health benefit substantiation, will be explained.
Developing infant nutrition products is a costly and time-consuming business. NIZO’s MicroColon model offers companies a solution to pre-screen ingredients, early in the development process. But could it be further optimised for the needs of infant nutrition companies? Guus explains this during this short video.
NIZO supports a healthy lifestyle by substantiating health benefits of food. In this video, Marjolijn Bragt of FrieslandCampina talks about her collaboration with @NIZO in an integrated approach to build a convincing case, in which the scientific and regulatory guidance, targeted preclinical studies, well-designed clinical trials, biomarker analysis and expert interpretation are combined.
NIZO supports a healthy lifestyle by substantiating health benefits of food. In this video, Ruud Albers, CEO of Nutrileads talks about his collaboration with NIZO in an integrated approach to build a convincing case, in which the scientific and regulatory guidance, targeted preclinical studies, well-designed clinical trials, biomarker analysis and expert interpretation are combined.
Understand your product’s impact on the body’s metabolic response and what this means for potential health benefits, through blood amino acid kinetics
Innovations in dairy and plant proteins offer exciting market opportunities for functional foods with health benefits. But many different elements play a role in how your ingredient influences the body’s metabolic response. The protein’s amino acid composition, its interaction with other nutrients in the end-product, its reaction to processing, etc. have to be considered. Even the consumer’s profile can make a difference: age, health and more.
Measuring concentrations of amino acids in the blood of healthy volunteers can offer key insight. For example, maintaining muscle mass is strongly associated with the stimulation of muscle protein synthesis after eating. Consuming proteins increases amino acid concentrations in the blood. Specific amino acids, including leucine, trigger the synthesis of muscle protein.
In clinical trials, we can compare the blood amino acid concentrations before and after the protein ingredient is consumed, to understand how the body is able to digest and make use of it.
NIZO can carry out digestion studies on your pure proteins or multi-component ingredients. For example:
NIZO can design and coordinate a customised protein digestion study, based on your specific question. We carry out your amino acid analyses in-house, for full control and enhanced efficiency. Using our expertise in food, science and nutrition, we can go even further: into the impact of the nutrient content, food matrix, processing, etc. on your protein ingredient.
We have extensive experience in clinical trials with different target populations, including both younger and older consumers (the ‘65-80’ year-old group), athletes, etc.
And while most protein digestion studies on amino acid patterns in the blood are done with isolated proteins, we have also carried out studies on actual products, delivering real-world insight.
For example, we have shown that protein composition isn’t the only factor that impacts amino acid availability in the blood. The product matrix (such as milk, yoghurt or cheese) also plays a role.
With our scientific expertise and guidance, we can help your company develop products that fit within more effective dietary strategies, whether for preventing muscle loss with aging or for meeting other consumer needs.