Solutions

Rapid screening of probiotics and prebiotics in a gut-like environment

Rapid screening of probiotics and prebiotics in a gut-like environment

New potential probiotics and prebiotics are identified on a daily basis and it is practically impossible to test all these bacteria and compounds in clinical trials. To pre-select the bacteria and compounds with the highest potential of exerting a probiotic or prebiotic function we have developed the Microcolon System.

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Optimal production of next generation probiotics

Optimal production of next generation probiotics

With our 68 years of expertise, we have successfully optimised and up-scaled the production of several next generation probiotics. Strains with potential probiotic benefits, selected from a healthy human gut and skin, were produced in our food grade NIZO Processing Centre, delivering viable biomass for human clinical trials.

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Identification of new Probiotics

Identification of new Probiotics

The identification of new probiotics that target a specific health issue is a major challenge. At our fermentation department, we have a large culture collection and unique expertise to assist companies in the identification of potentially probiotic strains that target specific mechanisms in relation to particular disease states. This research pipeline is called the ProBioSelect platform.

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Protein Overexpression and Bacterial Therapeutics

Protein Overexpression and Bacterial Therapeutics

We have developed the proprietary NICE system for overexpression of proteins in the food grade bacterium Lactococcus lactis. This system allows for tightly controlled expression of proteins using the food grade inducer peptide nisin. This system can be used as a safe platform for expression of proteins that have a potential to be used as biotherapeutics.

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Microbiota platform Insight in host-microbe interactions

Microbiota platform Insight in host-microbe interactions

NIZO has a microbiota profiling and quantification platform in place.

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Microcolon, Rapid screening of food ingredients

Microcolon, Rapid screening of food ingredients

NIZO food research has an established microcolon model that allows the high-throughput screening of novel ingredients and probiotics for their efficacy in the gastrointestinal tract.

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